文獻(xiàn)鏈接：https://rdcu.be/c0Kc1

文獻(xiàn)摘要

The neurologic manifestations of acute COVID-19 are well characterized, but a comprehensive evaluation of postacute neurologic

sequelae at 1 year has not been undertaken. Here we use the national healthcare databases of the US Department of Veterans

Affairs to build a cohort of 154,068 individuals with COVID-19, 5,638,795 contemporary controls and 5,859,621 historical controls;

we use inverse probability weighting to balance the cohorts, and estimate risks and burdens of incident neurologic disorders at

12 months following acute SARS-CoV-2 infection. Our results show that in the postacute phase of COVID-19, there was increased

risk of an array of incident neurologic sequelae including ischemic and hemorrhagic stroke, cognition and memory disorders,

peripheral nervous system disorders, episodic disorders (for example, migraine and seizures), extrapyramidal and movement

disorders, mental health disorders, musculoskeletal disorders, sensory disorders, Guillain–Barré syndrome, and encephalitis or

encephalopathy. We estimated that the hazard ratio of any neurologic sequela was 1.42 (95% confidence intervals 1.38, 1.47) and

burden 70.69 (95% confidence intervals 63.54, 78.01) per 1,000 persons at 12 months. The risks and burdens were elevated even

in people who did not require hospitalization during acute COVID-19. Limitations include a cohort comprising mostly White males.

Taken together, our results provide evidence of increased risk of long-term neurologic disorders in people who had COVID-19.

文獻(xiàn)發(fā)表于nature medicine，發(fā)表時間2022年9月22日