Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by

down-regulating cholesterol synthesis and altering detergent resistant membranes composition. Omega3脂肪酸通過下調(diào)膽固醇合成和改變DRM成分，增加多藥耐藥結(jié)腸癌細(xì)胞化學(xué)敏感性

The activity of P-glycoprotein (Pgp) and multidrug resistance related protein 1 (MRP1), two membrane transporters involved in multidrug resistance of colon cancer, is increased by high amounts of cholesterol in plasma membrane and detergent resistant membranes (DRMs). It has never been investigated whether omega 3 polyunsatured fatty acids (PUFAs), which modulate cholesterol homeostasis in dyslipidemic syndromes and have chemopreventive effects in colon cancer, may affect the response to chemotherapy in multidrug resistant (MDR) tumors.

糖蛋白(P-glycoprotein，Pgp)和多藥耐藥性相關(guān)蛋白1(re洗滌劑相關(guān)蛋白1，MRP1)是參與結(jié)腸癌多藥耐藥性的兩種膜轉(zhuǎn)運(yùn)蛋白，它們的活性通過質(zhì)膜和耐洗滌劑膜中大量的膽固醇而增加。Ω3多不飽和脂肪酸(PUFAs)調(diào)節(jié)血脂紊亂綜合征中的膽固醇平衡，對(duì)結(jié)腸癌具有化學(xué)預(yù)防作用，是否可能影響多藥耐藥(MDR)腫瘤的化療反應(yīng)，目前尚未有研究。