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【熱門產(chǎn)品推薦】恩弗利單抗,Envafolimab, AntibodySystem Laboratories

2023-06-08 08:46 作者:AtaGenix-普健生物  | 我要投稿

恩弗利單抗,Envafolimab,CAS: 2102192-68-5,AntibodySystem Laboratories


貨號:DHJ70104

產(chǎn)品鏈接:http://www.atagenix.com/product_detail-75183.html

別名:KN-035, CAS: 2102192-68-5

簡介:

恩弗利單抗? Envafolimab (ASC 22; KN 035) 是人源化的單域抗 PD-L1 抗體的重組蛋白。Envafolimab 是由抗 PD-L1 結(jié)構(gòu)域與人 IgG1 抗體的 Fc 片段融合而成。Envafolimab 阻斷 PD-L1 和 PD-1 之間的相互作用,IC50 值為 5.25?nM。Envafolimab 具有研究實體瘤的潛力。

貨號:DHJ70104

產(chǎn)品品牌:Antibodysystem

通用名;Envafolimab

純度:>95% by SDS-PAGE.

濃度:1mg/ml

Formulationicon:0.01M PBS, pH 7.4.

內(nèi)毒素:Please contact with the lab for this information.

別名:KN-035

靶點;物種:Human CD274/PD-L1/B7-H1

種類:Chimeric

受體鑒定:(VH-CH2-CH3)2

CAS:2102192-68-5

存儲條件:

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.


參考文獻(xiàn):


Envafolimab: First Approval. PMID: 35122636

Subcutaneous envafolimab monotherapy in patients with advanced defective mismatch repair/microsatellite instability high solid tumors. PMID: 34154614

First-in-Human Phase I Study of Envafolimab, a Novel Subcutaneous Single-Domain Anti-PD-L1 Antibody, in Patients with Advanced Solid Tumors. PMID: 33973293

Envafolimab - first PD-1/PD-L1 antibody to be administered by subcutaneous injection for microsatellite instability-high or deficient mismatch repair advanced solid tumors. PMID: 36124972

Phase I study of envafolimab (KN035), a novel subcutaneous single-domain anti-PD-L1 monoclonal antibody, in Japanese patients with advanced solid tumors. PMID: 35932387

Envafolimab combined with chemotherapy in the treatment of combined small cell lung cancer: A case report. PMID: 36874434

Case report: A case of complete clinical response in a patient experiencing high microsatellite instability unresectable colon cancer being treated with a PD-L1 inhibitor after interstitial pneumonia. PMID: 36998453

Design, synthesis, and preclinical evaluation of a novel bifunctional macrocyclic chelator for theranostics of cancers. PMID: 35347438

Residue-specific binding mechanisms of PD-L1 to its monoclonal antibodies by computational alanine scanning. PMID: 34259259

Noninvasive Imaging of Tumor PD-L1 Expression Using [99mTc]Tc-Labeled KN035 with SPECT/CT. PMID: 36541699


【熱門產(chǎn)品推薦】恩弗利單抗,Envafolimab, AntibodySystem Laboratories的評論 (共 條)

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