Name: Cyclosporin A/環(huán)孢素A/環(huán)孢菌素A

Synonym: cyclosporine; Ciclosporin; Cyclosporine A; Cyclosporin; Sandimmune;

Cas No: 59865-13-3

MF: C62H111N11O12

Molecular:1202.61

Sequence:Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl), ?BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA

從土壤真菌提取物中提取的環(huán)狀十一肽。它是一種對T淋巴細(xì)胞有特異作用的強(qiáng)大免疫抑制劑。

A ?cyclic undecapeptide from an extract of soil fungi. It is a powerful ? immunosupressant with a specific action on T-lymphocytes. It is used for ?the prophylaxis of graft rejection in organ and tissue transplantation.

環(huán)孢菌素是由某些絲孢綱(Hyphomycetes) ? 真菌如光澤柱孢菌(Cylindrocarpon lucidum)和膨大彎頸霉(Tolypocladium ? inflatum)的培養(yǎng)液中分離出的一種親脂性環(huán)狀多肽化合物，20世紀(jì)80年代作為免疫抑制劑已在世界范圍內(nèi)被廣泛應(yīng)用。 ? 環(huán)孢菌素一種很強(qiáng)的免疫抑制劑，可抑制細(xì)胞介質(zhì)的反應(yīng)發(fā)作，能可逆性抑制T細(xì)胞增殖，不抑制血細(xì)胞的生成，也不影響吞噬細(xì)胞功能，具有較少誘發(fā)或加重感染的優(yōu)點(diǎn)。